Enantioselective oxidation of 2-methyl-1-butanol by alcohol oxidase from methylotrophic yeasts

Dawn S. Clark; Shimona Geresh; Robert Di Cosimo

doi:10.1016/S0960-894X(00)80373-X

Enantioselective oxidation of 2-methyl-1-butanol by alcohol oxidase from methylotrophic yeasts

Dawn S. Clark
, Shimona Geresh
, Robert Di Cosimo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The oxidation of racemic 2-methyl-1-butanol by the soluble alcohol oxidase from Candida boidinii produced an enantiomeric excess of (R)-2-methyl-1-butanol (E = 1.65) as the reaction progressed. This degree of enantioselectivity was not observed with alcohol oxidase isolated from either Hansenula sp. or Pichia pastoris.

Original language	English
Pages (from-to)	1745-1748
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(00)80373-X
State	Published - 21 Jul 1994
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)80373-X

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title = "Enantioselective oxidation of 2-methyl-1-butanol by alcohol oxidase from methylotrophic yeasts",

abstract = "The oxidation of racemic 2-methyl-1-butanol by the soluble alcohol oxidase from Candida boidinii produced an enantiomeric excess of (R)-2-methyl-1-butanol (E = 1.65) as the reaction progressed. This degree of enantioselectivity was not observed with alcohol oxidase isolated from either Hansenula sp. or Pichia pastoris.",

author = "Clark, \{Dawn S.\} and Shimona Geresh and Cosimo, \{Robert Di\}",

year = "1994",

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T1 - Enantioselective oxidation of 2-methyl-1-butanol by alcohol oxidase from methylotrophic yeasts

AU - Clark, Dawn S.

AU - Geresh, Shimona

AU - Cosimo, Robert Di

PY - 1994/7/21

Y1 - 1994/7/21

N2 - The oxidation of racemic 2-methyl-1-butanol by the soluble alcohol oxidase from Candida boidinii produced an enantiomeric excess of (R)-2-methyl-1-butanol (E = 1.65) as the reaction progressed. This degree of enantioselectivity was not observed with alcohol oxidase isolated from either Hansenula sp. or Pichia pastoris.

AB - The oxidation of racemic 2-methyl-1-butanol by the soluble alcohol oxidase from Candida boidinii produced an enantiomeric excess of (R)-2-methyl-1-butanol (E = 1.65) as the reaction progressed. This degree of enantioselectivity was not observed with alcohol oxidase isolated from either Hansenula sp. or Pichia pastoris.

UR - https://www.scopus.com/pages/publications/0027990556

U2 - 10.1016/S0960-894X(00)80373-X

DO - 10.1016/S0960-894X(00)80373-X

M3 - Article

AN - SCOPUS:0027990556

SN - 0960-894X

VL - 4

SP - 1745

EP - 1748

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Enantioselective oxidation of 2-methyl-1-butanol by alcohol oxidase from methylotrophic yeasts

Abstract

ASJC Scopus subject areas

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