End-stage renal interstitial fibrosis in an adult ten years after ifosfamide therapy

Michael M. Friedlaender, Yosef S. Haviv, Eliezer Rosenmann, Nili Peylan-Ramu

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A 33-year-old male presented with end-stage renal failure. Renal biopsy showed severe interstitial fibrosis without glomerulopathy or vasculopathy. More than 10 years previously the patient had been successfully treated for recurrent rhabdomyosarcoma. The treatment included ifosfamide, a drug known to cause acute tubular dysfunction, Though a possible synergistic effect of previous radiation which was well within accepted tolerance limits cannot be excluded, it would appear that ifosfamide was almost certainly the major cause of the late onset chronic renal disease.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalAmerican Journal of Nephrology
Volume18
Issue number2
DOIs
StatePublished - 1 Mar 1998
Externally publishedYes

Keywords

  • Chronic renal failure
  • Ifosfamide
  • Interstitial fibrosis
  • Renal biopsy

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