Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

Yuanchao Ye, Marwa Abu El Haija, Donald A. Morgan, Deng Guo, Yang Song, Aaron Frank, Liping Tian, Ruth A. Riedl, Colin M.L. Burnett, Zhan Gao, Zhiyong Zhu, Shailesh K. Shahi, Kasra Zarei, Anne Couvelard, Nicolas Poté, Lara Ribeiro-Parenti, André Bado, Lama Noureddine, Andrew Bellizzi, Paul KievitAshutosh K. Mangalam, Leonid V. Zingman, Maude Le Gall, Justin L. Grobe, Lee M. Kaplan, Deborah Clegg, Kamal Rahmouni, Mohamad Mokadem

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The exact mechanisms underlying the metabolic effects of bariatric surgery remain unclear. Here, we demonstrate, using a combination of direct and indirect calorimetry, an increase in total resting metabolic rate (RMR) and specifically anaerobic RMR after Roux-en-Y gastric bypass (RYGB), but not sleeve gastrectomy (SG). We also show an RYGB-specific increase in splanchnic sympathetic nerve activity and “browning” of visceral mesenteric fat. Consequently, selective splanchnic denervation abolishes all beneficial metabolic outcomes of gastric bypass that involve changes in the endocannabinoid signaling within the small intestine. Furthermore, we demonstrate that administration of rimonabant, an endocannabinoid receptor-1 (CB1) inverse agonist, to obese mice mimics RYGB-specific effects on energy balance and splanchnic nerve activity. On the other hand, arachidonoylethanolamide (AEA), a CB1 agonist, attenuates the weight loss and metabolic signature of this procedure. These findings identify CB1 as a key player in energy regulation post-RYGB via a pathway involving the sympathetic nervous system.

Original languageEnglish
Article number108270
JournalCell Reports
Issue number4
StatePublished - 27 Oct 2020
Externally publishedYes


  • endocannabinoid receptor-1
  • energy expenditure
  • gastric bypass
  • obesity
  • resting metabolic rate
  • sleeve gastrectomy
  • sympathetic nervous system
  • thermogenesis

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass'. Together they form a unique fingerprint.

Cite this