Endogenous and synthetic cannabinoids: Recent advances

We have reviewed the effects of two endogenous cannabinoid constituents, anandamide and 2-Ara-G1, and of two synthetic cannabinoids, HU-211 and HU- 210. Anandamide partly parallels THC in most CNS activities; the lack of published data prevents comparison of 2-Ara-G1 with THC. Anandamide probably serves as a mediator in motor functions, in memory and, judging from the effects of THC in humans on mood and cognition, in emotions. 2-Ara-G1 probably plays a role in the immune system. HU-210, which is one of the most potent cannabinoids prepared so far as evidenced by observations on sedation, catalepsy and hypothermia, will presumably continue to serve as a potent tool for cannabinoid investigations. HU-211 which is not cannabimimetic, but is an NMDA antagonist, may become a drug used in neuroprotection and possibly in medical conditions associated with high levels of glutamate, tumor necrosis factor, and/or with impaired function of the BBB.