Endogenous cannabinoid ligands - Chemical and biological studies

R. Mechoulam, S. Ben Shabat, L. Hanuš, E. Fride, Z. Vogel, M. Bayewitch, A. E. Sulcova

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Arachidonic acid ethanolamide (anandamide) is a brain constituent that binds to the brain cannabinoid receptor (CB1). It produces many of the pharmacological effects caused by Δ9-tetrahydrocannabinol (Δ9-THC) in mice. Anandamide parallels Δ9-THC in its specific interaction with the cannabinoid receptor and in inhibition of adenylate cyclase. Two additional fatty acid ethanolamides that bind to the cannabinoid receptor, homo-γ-linolenylethanolamide and docostetraenylethanolamide, have been identified in the brain. We believe that the anandamides are involved in the coordination of movement and short term memory. Depression of ambulation in an open field and the analgetic response to anandamide are not fully developed until adulthood, possibly due to an age-related increase in the CB1 receptor concentration. This observation has clinical implications in pediatrics. A second cannabinoid receptor (CB2) is present in the spleen. A monoglyceride, 2-arachidonyl-glycerol which binds to both CB1 and CB2 in transfected cells and inhibits adenylate cyclase in spleen cells was found in the gut. Its role is apparently associated with the immune system. These fatty acids amides and esters represent a new family of chemical modulators in the body.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalJournal of Lipid Mediators and Cell Signalling
Volume14
Issue number1-3
DOIs
StatePublished - 1 Jan 1996
Externally publishedYes

Keywords

  • anandamides
  • cannabinoid receptor
  • docostetraenylethanolamide
  • homo-γ-linolenylethanolamide
  • pedi atrics

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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