Endogenous hepoxilin A3, produced under short duration of high shear-stress, inhibits thrombin-induced aggregation in human platelets

Alon Margalit, Yosef Granot

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The effect of short duration of shear-stress (350 dyne/cm2, 20 ms) on platelet-aggregation has been assessed. This treatment inhibits thrombin-induced but not ADP- or collagen-induced aggregation. The inhibitory effect is mediated by endogenous hepoxilin A3. This conclusion is based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A3 mimics the shear-stress effect.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1190
Issue number1
DOIs
StatePublished - 23 Feb 1994

Keywords

  • (Human)
  • Aggregation
  • Hepoxilin A
  • Platelet
  • Shear stress

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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