Abstract
The effect of short duration of shear-stress (350 dyne/cm2, 20 ms) on platelet-aggregation has been assessed. This treatment inhibits thrombin-induced but not ADP- or collagen-induced aggregation. The inhibitory effect is mediated by endogenous hepoxilin A3. This conclusion is based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A3 mimics the shear-stress effect.
Original language | English |
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Pages (from-to) | 173-176 |
Number of pages | 4 |
Journal | Biochimica et Biophysica Acta - Biomembranes |
Volume | 1190 |
Issue number | 1 |
DOIs | |
State | Published - 23 Feb 1994 |
Keywords
- (Human)
- Aggregation
- Hepoxilin A
- Platelet
- Shear stress
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Cell Biology