Endogenous hepoxilin A3, produced under short duration of high shear-stress, inhibits thrombin-induced aggregation in human platelets

Alon Margalit; Yosef Granot

doi:10.1016/0005-2736(94)90048-5

Endogenous hepoxilin A₃, produced under short duration of high shear-stress, inhibits thrombin-induced aggregation in human platelets

Alon Margalit, Yosef Granot

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effect of short duration of shear-stress (350 dyne/cm², 20 ms) on platelet-aggregation has been assessed. This treatment inhibits thrombin-induced but not ADP- or collagen-induced aggregation. The inhibitory effect is mediated by endogenous hepoxilin A₃. This conclusion is based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A₃ mimics the shear-stress effect.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1190
Issue number	1
DOIs	https://doi.org/10.1016/0005-2736(94)90048-5
State	Published - 23 Feb 1994

Keywords

(Human)
Aggregation
Hepoxilin A
Platelet
Shear stress

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

Access to Document

10.1016/0005-2736(94)90048-5

Cite this

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abstract = "The effect of short duration of shear-stress (350 dyne/cm2, 20 ms) on platelet-aggregation has been assessed. This treatment inhibits thrombin-induced but not ADP- or collagen-induced aggregation. The inhibitory effect is mediated by endogenous hepoxilin A3. This conclusion is based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A3 mimics the shear-stress effect.",

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N2 - The effect of short duration of shear-stress (350 dyne/cm2, 20 ms) on platelet-aggregation has been assessed. This treatment inhibits thrombin-induced but not ADP- or collagen-induced aggregation. The inhibitory effect is mediated by endogenous hepoxilin A3. This conclusion is based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A3 mimics the shear-stress effect.

AB - The effect of short duration of shear-stress (350 dyne/cm2, 20 ms) on platelet-aggregation has been assessed. This treatment inhibits thrombin-induced but not ADP- or collagen-induced aggregation. The inhibitory effect is mediated by endogenous hepoxilin A3. This conclusion is based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A3 mimics the shear-stress effect.

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KW - Shear stress

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