Endoreduplication in maize endosperm: Involvement of M phase-promoting factor inhibition and induction of S phase-related kinases

Gideon Grafi, Brian A. Larkins

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

Endoreduplication is an endonuclear chromosome duplication that occurs in the absence of mitosis and in Zea mays (L.) is required for endosperm development. Induction of DNA synthesis during early stages of endosperm development is maintained by increasing the amount and activity of S phase-related protein kinases, which was demonstrated here by their ability to interact with human E2F or with the adenovirus E1A proteins. In addition it was shown that endoreduplicated endosperm cells contain an inhibitor that suppresses the activity of the M phase-promoting factor (MPF). These results demonstrate that in maize endosperm, endoreduplication proceeds as a result of two events, inhibition of MPF and induction of S phase-related protein kinases.

Original languageEnglish
Pages (from-to)1262-1264
Number of pages3
JournalScience
Volume269
Issue number5228
DOIs
StatePublished - 1 Jan 1995
Externally publishedYes

ASJC Scopus subject areas

  • General

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