Endoscopic third ventriculostomy in patients with cerebrospinal fluid infection and/or hemorrhage

Vitaly Siomin, Giuseppe Cinalli, Andre Grotenhuis, Aprajay Golash, Shizuo Oi, Karl Kothbauer, Howard Weiner, Jonathan Roth, Liana Beni-Adani, Alain Pierre-Kahn, Yasuhiro Takahashi, Connor Mallucci, Rick Abbott, Jeffrey Wisoff, Shlomi Constantini

Research output: Contribution to journalArticlepeer-review

196 Scopus citations


Object. In this study the authors evaluate the safety, efficacy, and indications for endoscopic third ventriculostomy (ETV) in patients with a history of subarachnoid hemorrhage or intraventricular hemorrhage (IVH) and/or cerebrospinal fluid (CSF) infection. Methods. The charts of 101 patients from seven international medical centers were retrospectively reviewed; 46 patients had a history of hemorrhage, 42 had a history of CSF infection, and 13 had a history of both disorders. All patients experienced third ventricular hydrocephalus before endoscopy. The success rate for treatment in these three groups was 60.9, 64.3, and 23.1%, respectively. The follow-up period in successfully treated patients ranged from 0.6 to 10 years. Relatively minor complications were observed in 15 patients (14.9%), and there were no deaths. A higher rate of treatment failure was associated with three factors: classification in the combined infection/hemorrhage group, premature birth in the posthemorrhage group, and younger age in the postinfection group. A higher success rate was associated with a history of ventriculoperitoneal (VP) shunt placement before ETV in the posthemorrhage group, even among those who had been born prematurely, who were otherwise more prone to treatment failure. The 13 premature infants who had suffered an IVH and who had undergone VP shunt placement before ETV had a 100% success rate. The procedure was also successful in nine of 10 patients with primary aqueductal stenosis. Conclusions. Patients with obstructive hydrocephalus and a history of either hemorrhage or infection may be good candidates for ETV, with safety and success rates comparable with those in more general series of patients. Patients who have sustained both hemorrhage and infection are poor candidates for ETV, except in selected cases and as a treatment of last resort. In patients who have previously undergone shunt placement posthemorrhage, ETV is highly successful. It is also highly successful in patients with primary aqueductal stenosis, even in those with a history of hemorrhage or CSF infection.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalJournal of Neurosurgery
Issue number3
StatePublished - 1 Jan 2002
Externally publishedYes


  • Endoscopic third ventriculostomy
  • Hemorrhage
  • Hydrocephalus
  • Infection
  • Premature infant

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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