Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays

M. Shein, A. Greenbaum, T. Gabay, R. Sorkin, M. David-Pur, E. Ben-Jacob, Y. Hanein

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Standard micro-fabrication techniques which were originally developed to fabricate semi-conducting electronic devices were inadvertently found to be adequate for bio-chip fabrication suited for applications such as stimulation and recording from neurons in-vitro as well as in-vivo. However, cell adhesion to conventional micro-chips is poor and chemical treatments are needed to facilitate the interaction between the device surface and the cells. Here we present novel carbon nanotube-based electrode arrays composed of cell-alluring carbon nanotube (CNT) islands. These play a double role of anchoring neurons directly and only onto the electrode sites (with no need for chemical treatments) and facilitating high fidelity electrical interfacing - recording and stimulation. This method presents an important step towards building nano-based neurochips of precisely engineered networks. These neurochips can provide unique platform for studying the activity patterns of ordered networks as well as for testing the effects of network damage and methods of network repair.

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalBiomedical Microdevices
Issue number2
StatePublished - 1 Jan 2009
Externally publishedYes


  • Carbon nanotubes
  • Circuit
  • Electrodes
  • Neurochip
  • Stimulation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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