Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations

Keyphrases

• Down Syndrome 100%
• Overdosage 100%
• Splicing Aberrations 100%
• DYRK1A 100%
• Acetylcholinesterase 41%
• Synaptic 16%
• Brain Function 16%
• Splicing Process 16%
• Splicing Machinery 16%
• Overexpression 8%
• Regulatory Role 8%
• Overexpressing 8%
• Synaptogenesis 8%
• Synaptic Proteins 8%
• RNA Transcripts 8%
• Further Analysis 8%
• Exon Inclusion 8%
• Splicing Event 8%
• Ts65Dn 8%
• Amplification Effect 8%
• Nuclear Speckles 8%
• Signal Amplification 8%
• Gene Dosage 8%
• Partial Trisomy 8%
• Protein Phosphorylation 8%
• Axon Guidance 8%
• Fetal Brain 8%
• Cell Fate Determination 8%
• Regulatory Mechanism 8%
• Splicing Pattern 8%
• Brain Samples 8%
• SR Proteins 8%
• Stress-inducible 8%
• Target Transcript 8%
• Dominant Negative 8%
• Neuroligin 8%
• Parallel Changes 8%
• Therapeutic Manipulation 8%
• Minigene 8%

Biochemistry, Genetics and Molecular Biology

• Down Syndrome 100%
• DYRK1A 100%
• Messenger RNA 33%
• Acetylcholinesterase 33%
• Mouse 16%
• Brain Function 16%
• Animal Model 8%
• Kinase 8%
• Phosphotransferase 8%
• Exon 8%
• Acetylcholinesterase 8%
• Cell Fate Determination 8%
• Axon Guidance 8%
• Gene Dosage 8%
• SR Protein 8%
• Trisomy 8%
• Neuroligin 8%
• Protein Phosphorylation 8%
• Minigene 8%
• Information Retrieval 8%
• Brain-Derived Neurotrophic Factor 8%
• Synaptogenesis 8%