Enhanced antiinflammatory activity of diclofenac in Jojoba oil submicron emulsion cream

J. S. Schwarz, M. R. Weisspapir, A. Shani, S. Amselem

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Jojoba liquid wax is a stable highly lipophilic, non-irritative and non-toxic 'oil', obtained from desert plant Jojoba (Simmondsia chinensis). The potential use of Jojoba oil as excipient for the preparation of submicron emulsions (SME) for topical use was investigated. Submicron oil-in-water emulsion containing 20% Jojoba oil and the antiinflammatory drug Diclofenac Diethylammonium (1.16%) was prepared by a proprietary high pressure homogenization technique (mean droplet size about 150 nm). The effectiveness of the 1.16% Diclofenac Diethylammonium in the Jojoba SME topical cream was evaluated in carrageenan paw edema model. Diclofenac in Jojoba SME vehicle demonstrated significantly greater antiinflammatory activity than marketed Voltaren® Emulgel® cream (Ciba-Geigy). The unique penetrative properties of the SME delivery technology makes this novel topical vehicle attractive for development in cosmetic formulations. Water-insoluble substances used in personal care products as antioxidants and vitamins such as tocopherols (vitamin E), retinoids (vitamin A) have been successfully incorporated in SME formulations. The solvent-free SME technology can be also considered for use in cosmetic preparations to replace alcohols used as solvents and coolants (e.g. after-shaves and antiseptic solutions). Additional potential cosmetic uses of interest for SME lipoidal vehicle in the form of lotions, gels, or creams might include hair-lotions, sunscreens, after-sun gels, and encapsulation of fragrances and perfumes.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalJournal of Applied Cosmetology
Issue number1
StatePublished - 1 Jan 1996
Externally publishedYes


  • Jojoba oil
  • Jojoba wax
  • carrageenan paw edema model
  • diclofenac
  • oil-in-water emulsions
  • submicron emulsion

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Enhanced antiinflammatory activity of diclofenac in Jojoba oil submicron emulsion cream'. Together they form a unique fingerprint.

Cite this