Enhanced erythrocyte adhesiveness/aggregation in obesity corresponds to low-grade inflammation

Dorit Samocha-Bonet, Dov Lichtenberg, Aaron Tomer, Varda Deutsch, Tamar Mardi, Yelena Goldin, Subchi Abu-Abeid, Galina Shenkerman, Hana Patshomik, Itzhak Shapira, Shlomo Berliner

    Research output: Contribution to journalArticlepeer-review

    42 Scopus citations

    Abstract

    Objective: Previous studies have suggested that obesity enhances the inflammatory response, producing macromolecules involved in the induction and/or maintenance of increased erythrocyte aggregation. The objectives of this study were to evaluate the correlation between inflammation markers, erythrocyte adhesiveness/aggregation, and the degree of obesity and to assess phosphatidylserine expression on erythrocyte surface membrane of obese vs. nonobese individuals. Research Methods and Procedures: Erythrocyte adhesiveness/aggregation in the peripheral venous blood was evaluated by using a new biomarker, phosphatidylserine expression was assessed by means of flow cytometry, and markers of inflammation were measured in 65 subjects: 30 obese [body mass index (BMI) = 41 ± 7.7 kg/m2] and 35 nonobese (BMI = 24 ± 2.7 kg/m2) individuals. Pearson correlations and Student's t test were performed. Results: A highly significant difference was noted in the degree of erythrocyte adhesiveness/aggregation and markers of inflammation between the study groups. BMI correlated with erythrocyte adhesiveness/aggregation (r = 0.42, p = 0.001), erythrocyte sedimentation rate (r = 0.42, p = 0.001), high-sensitive C-reactive protein (r = 0.55, p < 10-4), fibrinogen (r = 0.37, p = 0.004), and white blood cell count (r = 0.45, p < 10-4). The degree of erythrocyte adhesiveness/aggregation correlated with erythrocyte sedimentation rate (r = 0.5, p < 10-4), high-sensitive C-reactive protein (r = 0.56, p < 10-4), fibrinogen (r = 0.54, p < 10-4), and white blood cell count (r = 0.32, p = 0.01). Discussion: Our results suggest that obesity-related erythrocyte adhesiveness/aggregation is probably mediated through increased concentrations of adhesive macromolecules in the circulation and not necessarily through hyperlipidemia or phosphatidylserine exposure on erythrocyte's membrane.

    Original languageEnglish
    Pages (from-to)403-407
    Number of pages5
    JournalObesity Research
    Volume11
    Issue number3
    DOIs
    StatePublished - 1 Jan 2003

    Keywords

    • Erythrocyte aggregability
    • Inflammation markers
    • Phosphatidylserine

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Food Science
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Public Health, Environmental and Occupational Health

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