Abstract
The pore-forming antibacterial peptide magainin 2 was made divalent, tetravalent, and octavalent via a copper(I)-mediated 1-3 dipolar cycloaddition reaction ("click" chemistry). This series of pore-forming compounds was tested in vitro for their ability to form pores in large unilamillar vesicles (LUVs). A large increase in the pore-forming capability was especially observed with the tetravalent and octavalent magainin compounds in the LUVs consisting of DOPC, and the octavalent magainin compound showed a marked increase with the DOPC/DOPG LUVs. Activity was observed in the low nanomolar range for these compounds.
Original language | English |
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Pages (from-to) | 13437-13442 |
Number of pages | 6 |
Journal | Biochemistry |
Volume | 46 |
Issue number | 46 |
DOIs | |
State | Published - 20 Nov 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry