Enhancing Mechanical Stimulated Brillouin Scattering Imaging with Physics-Driven Model Selection

Roni Shaashoua, Tal Levy, Barak Rotblat, Alberto Bilenca

Research output: Contribution to journalArticlepeer-review

Abstract

Brillouin microscopy (BM) is an emerging technique for all-optical mechanical imaging without the need for physical contact with the sample or for an external mechanical stimulus. However, BM often retrieves a single Brillouin frequency shift for multiple mechanically different materials of structures and/or in regions—sufficiently larger than the phonon wavelength—inside the volume and its surroundings, resulting in significantly limited mechanical specificity in the Brillouin shift images produced. Here, a new physics-driven model selection framework is developed based on information theory and a physical-statistical overfit Brillouin water peak threshold that enables the robust identification of single- and multi-peak Brillouin signatures in the sample pixels. The model selection framework is applied to Brillouin data of material interfaces and living NIH/3T3 cells measured by stimulated Brillouin scattering (SBS) microscopy, facilitating the quantification of the Brillouin frequency shift of materials in different regions of the sample and significantly improving mechanical specificity compared with the standard single peak fitting analysis.

Original languageEnglish
JournalLaser and Photonics Reviews
DOIs
StateAccepted/In press - 1 Jan 2024

Keywords

  • brillouin imaging
  • brillouin microscopy
  • mechanical imaging
  • stimulated Brillouin scattering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics

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