Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides

Cristina Chamorro, Marcel A. Boerman, Christopher J. Arnusch, Eefjan Breukink, Roland J. Pieters

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

In order to enhance the membrane disruption of antimicrobial peptides both targeting and multivalent presentation approaches were explored. The antimicrobial peptides anoplin and temporin L were conjugated via click chemistry to vancomycin and to di- and tetravalent dendrimers. The vancomycin unit led to enhanced membrane disruption of large unilamellar vesicles (LUVs) displaying the vancomycin target lipid II, but only for temporin L and not for anoplin. The multivalent presentation led to enhanced LUV membrane disruption in the case of anoplin but not for temporin L.

Original languageEnglish
Pages (from-to)2171-2174
Number of pages4
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1818
Issue number9
DOIs
StatePublished - 1 Sep 2012

Keywords

  • Anoplin
  • Antimicrobial peptide
  • Membrane disruption
  • Multivalency
  • Targeting
  • Temporin L

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