Abstract
Polyvinylidene fluoride (PVDF) has gained attention as a promising material for tissue engineering due to its biocompatibility and piezoelectricity. However, achieving proper cell adhesion to PVDF surfaces remains a challenge. This study focuses on the preparation and characterization of PVDF-based substrates, including PVDF thin films and nanocomposites incorporating CoFe2O4 magnetic nanoparticles. Helium plasma treatment is employed to modify the surface properties of these substrates. The plasma treatment induces significant changes in the topography of the PVDF-based nanocomposites. The roughness values of the samples increase from 2–3 nm to 14–17 nm after 90 s of plasma treatment, leading to enhanced hydrophilicity with an average contact angle below 60°. Importantly, the helium plasma treatment preserves the magnetic and structural properties of the substrates, suggesting the retention of their magnetoelectric properties and, thus treated composites hold potential for remote stem cell activation. We provide evidence of cytocompatibility and improved adhesive properties of plasma-treated substrates using human mesenchymal stem cell cultures.
Original language | English |
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Article number | 126567 |
Journal | Polymer |
Volume | 290 |
DOIs | |
State | Published - 5 Jan 2024 |
Externally published | Yes |
Keywords
- Cell adhesion
- Helium plasma
- Magnetic nanoparticles
- PVDF
- Plasma treatments
- Polymer composite
- Surface wettability
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry