Enhancing wettability and adhesive properties of PVDF-based substrates through non-thermal helium plasma surface modification

V. Antipova, A. Omelyanchik, K. Sobolev, S. Pshenichnikov, S. Vorontsov, E. Korepanova, D. Schitz, D. Peddis, L. Panina, K. Levada, V. Rodionova

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Polyvinylidene fluoride (PVDF) has gained attention as a promising material for tissue engineering due to its biocompatibility and piezoelectricity. However, achieving proper cell adhesion to PVDF surfaces remains a challenge. This study focuses on the preparation and characterization of PVDF-based substrates, including PVDF thin films and nanocomposites incorporating CoFe2O4 magnetic nanoparticles. Helium plasma treatment is employed to modify the surface properties of these substrates. The plasma treatment induces significant changes in the topography of the PVDF-based nanocomposites. The roughness values of the samples increase from 2–3 nm to 14–17 nm after 90 s of plasma treatment, leading to enhanced hydrophilicity with an average contact angle below 60°. Importantly, the helium plasma treatment preserves the magnetic and structural properties of the substrates, suggesting the retention of their magnetoelectric properties and, thus treated composites hold potential for remote stem cell activation. We provide evidence of cytocompatibility and improved adhesive properties of plasma-treated substrates using human mesenchymal stem cell cultures.

Original languageEnglish
Article number126567
JournalPolymer
Volume290
DOIs
StatePublished - 5 Jan 2024
Externally publishedYes

Keywords

  • Cell adhesion
  • Helium plasma
  • Magnetic nanoparticles
  • PVDF
  • Plasma treatments
  • Polymer composite
  • Surface wettability

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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