Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors

Abraham Danon, Murray Heimberg, John A. Oates

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


1. 1. The effects of supplementation of a complete diet with ethyl arachidonate and with ethyl dihomo-γ-linolenate (20 : 3ω6) on the fatty acid composition of plasma and tissue lipid classes were studied in normal rats. 2. 2. These prostaglandin precursors were incorporated in varying degrees into all lipid classes of the tissues that were investigated. The largest elevations were seen in plasma and tissue triacylglycerols. Significant increases were also observed in phospholipids, cholesteryl esters and the free fatty acid fraction. 3. 3. Following the feeding of the ester of 20 : 3ω6, arachidonate levels also rose in the lipids of some tissues. In others, such as the renal medulla and platelets, an increase in 20 : 3ω6 content occurred without a rise in 20 : 4. 4. 4. Platelet aggregation is known to be stimulated by 20 : 4 (via active metabolites), but not by 20 : 3ω6. The ability to modify 20 : 3ω6 levels selectively in certain tissues is of interest in light of such pharmacologic differences from 20 : 4.

Original languageEnglish
Pages (from-to)318-330
Number of pages13
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Issue number3
StatePublished - 23 Jun 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology


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