This study deals with policy instruments supporting high-tech start-up activity. It is based on the Israeli experience with two specific government programmes: Yozma, which triggered the emergence of the venture capital industry, and the technological incubators programme. These programmes had significant impact on the development of the high-tech cluster in Israel. While venture capital has positive impact on the growth and strength of high-tech clusters, it has also significant drawbacks, such as narrow geographical distribution of high-tech activities and narrow technological diversification. In this study we will analyse whether the interaction between Yozma programme and the technological incubators programme, reduced these drawbacks. We will examine whether the technological incubators in peripheral areas in Israel succeeded in attracting high-tech start-up activity as well as venture capital investments, and whether the incubators were supporting more diversified technological fields than the venture capital industry. In addition, we will try to determine whether cooperation between venture capitals and incubators led to more balanced investments patterns in terms of geographical distribution and technological diversification. Our empirical work is based on a population of 3747 Israeli high-tech firms, established between 1991 and 2004. In analysing this data we will attempt to determine whether venture capitals and incubators have dissimilar effectiveness in supporting start-ups and different technological and geographical preferences. The findings suggest that while venture capital-backed firms have higher success rates, their activities are more concentrated in central areas. In contrast, the technological incubators proved successful in attracting activity to peripheral areas and to less popular technologies, but their success rates are very low. Finally, the findings suggest that incubator graduates that received venture capital financing had significantly improved results.