Environmental pollutants induce noninherited antibiotic resistance to polymyxin B in Escherichia coli

Dorin Harpaz, Robert S. Marks, Ariel Kushmaro, Evgeni Eltzov

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aim: The mechanisms behind antibiotic resistance by bacteria are important to create alternative molecules. Objective: This study focuses on the impact of environmental pollutants on bacterial resistance to antibiotics. Materials & methods: The effect of various environmental pollutants on noninherited bacterial resistance to antibiotics was examined. Results: The tolerance to the polymyxin-B antibiotic was shown to be conferred to Escherichia coli, by pretreatment with subinhibitory concentrations of environmental toxicants. The cell survival to a sublethal dosage of antibiotics was tested. Exposure to low concentrations of toxic compounds (500 ppb copper, 2% [v/v] ethanol or 0.5 μg/ml trimethoprim) stimulated the bacterial heat shock systems and led to increased tolerance to polymyxin B. Conclusion: Environmental pollutants induce a temporary bacterial noninheritable resistance to antibiotic.

Original languageEnglish
Pages (from-to)1631-1643
Number of pages13
JournalFuture Microbiology
Volume15
Issue number17
DOIs
StatePublished - 1 Nov 2020

Keywords

  • E. coli
  • antibiotic resistance
  • bacteria
  • environmental pollutants
  • noninherited resistance
  • polymyxin B

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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