Environmental Stresses Disrupt Telomere Length Homeostasis

Gal Hagit Romano, Yaniv Harari, Tal Yehuda, Ariel Podhorzer, Linda Rubinstein, Ron Shamir, Assaf Gottlieb, Yael Silberberg, Dana Pe'er, Eytan Ruppin, Roded Sharan, Martin Kupiec

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease. Recent studies have additionally found a correlation between psychological stress, telomere length, and health outcome in humans. However, studies have not yet explored the causal relationship between stress and telomere length, or the molecular mechanisms underlying that relationship. Using yeast as a model organism, we show that stresses may have very different outcomes: alcohol and acetic acid elongate telomeres, whereas caffeine and high temperatures shorten telomeres. Additional treatments, such as oxidative stress, show no effect. By combining genome-wide expression measurements with a systematic genetic screen, we identify the Rap1/Rif1 pathway as the central mediator of the telomeric response to environmental signals. These results demonstrate that telomere length can be manipulated, and that a carefully regulated homeostasis may become markedly deregulated in opposing directions in response to different environmental cues.

Original languageEnglish
Article numbere1003721
JournalPLoS Genetics
Volume9
Issue number9
DOIs
StatePublished - 1 Sep 2013
Externally publishedYes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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