Enzymatic Debridement of Deep Thermal Burns in the Russian Federation: First Experience

Andrey A. Alekseev, Natalia B. Malyutina, Alexander E. Bobrovnikov, Yaron Shoham

    Research output: Contribution to journalArticlepeer-review


    Since its approval in Europe a decade ago, NexoBrid® enzymatic debridement of deep thermal burns has been gaining acceptance as standard practice around the world. The purpose of this study is to report the first experience with NexoBrid® in the Russian Federation. During 2019–2020, we conducted a post-registration clinical study assessing the safety and treatment results of NexoBrid® enzymatic debridement. The study involved 15 adult patients suffering from deep thermal burns over an area ≤15% of their total body surface area. Patients were treated with NexoBrid® within 3 days of injury, followed by spontaneous or surgical wound closure. Complete eschar removal was achieved in twelve patients, 80% eschar removal in two patients, and 70% in one patient. Complete spontaneous epithelialization of wounds was achieved in 12 patients (80%) within 18 ± 1.9 days after the start of treatment. We did not witness pathological scarring during follow-up, and there were no significant safety issues throughout the study. Early use of NexoBrid® resulted in rapid, effective, and safe eschar removal with good results and sufficient preservation of viable dermis to allow for spontaneous healing in 80% of patients. These results demonstrate the ability to minimize surgical intervention and hopefully lead to better long-term scarring results.

    Original languageEnglish
    Article number488
    Issue number2
    StatePublished - 1 Feb 2023


    • deep thermal burns
    • enzymatic debridement
    • mixed depth burns
    • NexoBrid
    • spontaneous healing

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Biochemistry, Genetics and Molecular Biology (all)
    • Space and Planetary Science
    • Paleontology


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