Enzymatically controlled responsive drug delivery systems

Riki Goldbart, Tamar Traitel, Smadar A. Lapidot, Joseph Kost

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


This paper discusses two approaches for the preparation of enzymatically controlled drug delivery systems: (i) a calcium-responsive biodegradable drug delivery system based on a mixture of starch with HPMC (hydroxypropyl methyl cellulose ether) (biodegradable) and the starch hydrolytic enzyme, α-amylase, in its non-active form; (ii) a glucose-responsive insulin delivery system based on the hydrogel poly(2-hydroxyethyl methacrylate-co-N,N-dimethylaminoethyl methacrylate), with entrapped glucose oxidase, catalase and insulin. In both systems, the sensitivity to a trigger molecule (calcium or glucose) was achieved by the incorporation of a specific enzyme that reacts with the trigger molecule. Based on these interactions we propose two different enzyme-controlled drug release mechanisms for responsive drug delivery systems.

Original languageEnglish
Pages (from-to)1006-1018
Number of pages13
JournalPolymers for Advanced Technologies
Issue number10-12
StatePublished - 1 Jan 2002


  • Calcium-responsive
  • Controlled drug delivery
  • Enzymatically controlled
  • Glucose-responsive
  • Insulin release

ASJC Scopus subject areas

  • Polymers and Plastics


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