Eosinophil levels predict lung function deterioration in apparently healthy individuals

Udi Shapira, Mor Krubiner, Michal Ehrenwald, Itzhak Shapira, David Zeltser, Shlomo Berliner, Ori Rogowski, Shani Shenhar-Tsarfaty, Amir Bar-Shai

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: While chronic respiratory diseases are among the leading causes of mortality and morbidity worldwide, little is known about the effect of blood eosinophil levels on lung function trajectories among healthy individuals. Methods: We analyzed data of apparently healthy individuals (n=18,089) recruited for the Tel Aviv Medical Center Inflammation Survey. Blood eosinophil levels were compared between participants with normal and those with abnormal lung function. Multivariate regression was used to assess the OR of forced expiratory volume in 1 second (FEV 1 ) deterioration according to baseline eosinophils in subjects with normal lung function (n=4,141) during a follow-up period of 4 years. Results: Participants with an abnormal, as opposed to a normal, pulmonary function test (PFT) (n=1,832, 10.1%) had significantly higher eosinophil levels, expressed as a percentage or count (2.99%±2.00% compared to 2.67%±1.88% and 0.2210e3/µL±0.163/µL compared to 0.1810e3/µL±0.183/µL, respectively; P<0.001 for both). Among participants with a normal PFT at baseline, those with an eosinophil percentage higher than 4% showed a higher risk for FEV1decline above 60 mL/year (OR=1.199, 95% CI=1.005–1.431, P=0.044). Conclusion: Our study suggests that higher blood eosinophil levels can predict PFT deterioration even in apparently healthy subjects, implying that these individuals could benefit from frequent lung function evaluation.

Original languageEnglish
Pages (from-to)597-603
Number of pages7
JournalInternational Journal of COPD
StatePublished - 1 Jan 2019


  • Eosinophils
  • Inflammation
  • Lung function
  • Normal population
  • Trajectory

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Eosinophil levels predict lung function deterioration in apparently healthy individuals'. Together they form a unique fingerprint.

Cite this