Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (CMP-PA)

M. H. Richards; R. H. Belmaker

doi:10.1007/BF01271188

Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (CMP-PA)

M. H. Richards, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

In CHOm3 cells and rat cerebral cortex slices, epi-inositol was less potent but as effective as myo-inositol in reversing carbachol/lithium-stimulated CMP-PA accumulation whereas L-chiro-and scyllo-inositol were less active or inactive. These results with the four inositol isomers in two tissues correlate exactly with their effects on lithium-pilocarpine induced seizures and suggest a common mechanism of action for biochemical and behavioural effects.

Original language	English
Pages (from-to)	1281-1285
Number of pages	5
Journal	Journal of Neural Transmission
Volume	103
Issue number	11
DOIs	https://doi.org/10.1007/BF01271188
State	Published - 1 Jan 1996

Keywords

Cytidine monophosphorylphosphatidate
Epi-inositol
L-chiro-inositol
Myo-inositol
Scyllo-inositol

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/BF01271188

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title = "Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (CMP-PA)",

abstract = "In CHOm3 cells and rat cerebral cortex slices, epi-inositol was less potent but as effective as myo-inositol in reversing carbachol/lithium-stimulated CMP-PA accumulation whereas L-chiro-and scyllo-inositol were less active or inactive. These results with the four inositol isomers in two tissues correlate exactly with their effects on lithium-pilocarpine induced seizures and suggest a common mechanism of action for biochemical and behavioural effects.",

keywords = "Cytidine monophosphorylphosphatidate, Epi-inositol, L-chiro-inositol, Myo-inositol, Scyllo-inositol",

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AU - Richards, M. H.

AU - Belmaker, R. H.

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Y1 - 1996/1/1

N2 - In CHOm3 cells and rat cerebral cortex slices, epi-inositol was less potent but as effective as myo-inositol in reversing carbachol/lithium-stimulated CMP-PA accumulation whereas L-chiro-and scyllo-inositol were less active or inactive. These results with the four inositol isomers in two tissues correlate exactly with their effects on lithium-pilocarpine induced seizures and suggest a common mechanism of action for biochemical and behavioural effects.

AB - In CHOm3 cells and rat cerebral cortex slices, epi-inositol was less potent but as effective as myo-inositol in reversing carbachol/lithium-stimulated CMP-PA accumulation whereas L-chiro-and scyllo-inositol were less active or inactive. These results with the four inositol isomers in two tissues correlate exactly with their effects on lithium-pilocarpine induced seizures and suggest a common mechanism of action for biochemical and behavioural effects.

KW - Cytidine monophosphorylphosphatidate

KW - Epi-inositol

KW - L-chiro-inositol

KW - Myo-inositol

KW - Scyllo-inositol

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JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 11

ER -

Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (CMP-PA)

Abstract

Keywords

ASJC Scopus subject areas

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