Abstract
In CHOm3 cells and rat cerebral cortex slices, epi-inositol was less potent but as effective as myo-inositol in reversing carbachol/lithium-stimulated CMP-PA accumulation whereas L-chiro-and scyllo-inositol were less active or inactive. These results with the four inositol isomers in two tissues correlate exactly with their effects on lithium-pilocarpine induced seizures and suggest a common mechanism of action for biochemical and behavioural effects.
| Original language | English |
|---|---|
| Pages (from-to) | 1281-1285 |
| Number of pages | 5 |
| Journal | Journal of Neural Transmission |
| Volume | 103 |
| Issue number | 11 |
| DOIs | |
| State | Published - 1 Jan 1996 |
Keywords
- Cytidine monophosphorylphosphatidate
- Epi-inositol
- L-chiro-inositol
- Myo-inositol
- Scyllo-inositol
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
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