Epidemiology of gliomas in Israel: A nationwide study

Siegal Sadetzki, Leor Zach, Angela Chetrit, Dvora Nass, Chen Hoffmann, Zvi Ram, Menashe Zaaroor, Felix Umansky, Zvi Harry Rappaport, Avi Cohen, Uriel Wald, Sigmund Rothman, Moshe Hadani

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: Glial brain tumors span a wide range of neoplasms with distinct clinical and histopathological features. This report presents the descriptive epidemiology of glial tumors by histological subtype and tumor behavior. Methods: The study population included all incident cases of glial tumors diagnosed in Israel during March 2001 to July 2003. Age-standardized incidence rates (ASR) were calculated using the world population as a standard. Results: A total of 548 tumors were diagnosed, of which 520 had histological confirmation. The ASR of all adult (>20 years) glial tumors was 5.82/100,000 (7.11 for males; 4.75 for females, p < 0.001). The majority of tumors (78%) were classified as high grade; astrocytic tumors were the most frequent (85%), with glioblastoma multiforme accounting for 70% of them. A significant positive association was shown between age at diagnosis and grade. The highest ASR was seen for Europe- and-American-born, followed by Israeli, Asian and African-born individuals (6.78, 5.86, 4.94 and 3.84/100,000, respectively). Conclusions: In general, these results describing data of incident cases of pathologically validated glial tumors are consistent with previous reports. To enhance our understanding of these diseases, epidemiological studies should rely on well-defined histological tumor types, incorporating comprehensive information which will allow comparability between different groups of patients.

Original languageEnglish
Pages (from-to)264-269
Number of pages6
Issue number4
StatePublished - 1 Nov 2008
Externally publishedYes


  • Descriptive epidemiology, Israel
  • Glioma, incidence rates

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology


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