Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis

Yekaterina A. Miroshnikova, Idan Cohen, Elena Ezhkova, Sara A. Wickström

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume55
DOIs
StatePublished - 1 Apr 2019
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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