Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135

O. Kofman; R. Tarrasch; M. Mintz; Myslobodsky M.S.

doi:10.1016/0361-9230(92)90091-B

Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135

O. Kofman, R. Tarrasch, M. Mintz, Myslobodsky M.S.

Research output: Contribution to journal › Article › peer-review

Abstract

The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABA_A receptor antagonist, these findings suggest that GABA_A receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.

Original language	English
Pages (from-to)	511-514
Number of pages	4
Journal	Brain Research Bulletin
Volume	29
Issue number	3-4
DOIs	https://doi.org/10.1016/0361-9230(92)90091-B
State	Published - 1 Jan 1992
Externally published	Yes

Keywords

Amygdala Epilepsy Scizures Steroid Amidine R 5135

ASJC Scopus subject areas

Neuroscience (all)

Access to Document

10.1016/0361-9230(92)90091-B

Cite this

@article{178cae0cc8ae41d58fb1f23106806d81,

title = "Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135",

abstract = "The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABAA receptor antagonist, these findings suggest that GABAA receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.",

keywords = "Amygdala Epilepsy Scizures Steroid Amidine R 5135",

author = "O. Kofman and R. Tarrasch and M. Mintz and Myslobodsky M.S.",

year = "1992",

month = jan,

day = "1",

doi = "10.1016/0361-9230(92)90091-B",

language = "English",

volume = "29",

pages = "511--514",

journal = "Brain Research Bulletin",

issn = "0361-9230",

publisher = "Elsevier Inc.",

number = "3-4",

}

TY - JOUR

T1 - Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135

AU - Kofman, O.

AU - Tarrasch, R.

AU - Mintz, M.

AU - M.S., Myslobodsky

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABAA receptor antagonist, these findings suggest that GABAA receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.

AB - The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABAA receptor antagonist, these findings suggest that GABAA receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.

KW - Amygdala Epilepsy Scizures Steroid Amidine R 5135

UR - http://www.scopus.com/inward/record.url?scp=0026785568&partnerID=8YFLogxK

U2 - 10.1016/0361-9230(92)90091-B

DO - 10.1016/0361-9230(92)90091-B

M3 - Article

AN - SCOPUS:0026785568

VL - 29

SP - 511

EP - 514

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 3-4

ER -

Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this