Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135

O. Kofman; R. Tarrasch; M. Mintz; Myslobodsky M.S.

doi:10.1016/0361-9230(92)90091-B

Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135

O. Kofman, R. Tarrasch, M. Mintz, Myslobodsky M.S.

Research output: Contribution to journal › Article › peer-review

Abstract

The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABA_A receptor antagonist, these findings suggest that GABA_A receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.

Original language	English
Pages (from-to)	511-514
Number of pages	4
Journal	Brain Research Bulletin
Volume	29
Issue number	3-4
DOIs	https://doi.org/10.1016/0361-9230(92)90091-B
State	Published - 1 Jan 1992
Externally published	Yes

Keywords

Amygdala Epilepsy Scizures Steroid Amidine R 5135

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0361-9230(92)90091-B

Cite this

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title = "Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135",

abstract = "The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABAA receptor antagonist, these findings suggest that GABAA receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.",

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AU - Tarrasch, R.

AU - Mintz, M.

AU - M.S., Myslobodsky

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AB - The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABAA receptor antagonist, these findings suggest that GABAA receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.

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Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135

Abstract

Keywords

ASJC Scopus subject areas

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