Abstract
The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABAA receptor antagonist, these findings suggest that GABAA receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.
Original language | English |
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Pages (from-to) | 511-514 |
Number of pages | 4 |
Journal | Brain Research Bulletin |
Volume | 29 |
Issue number | 3-4 |
DOIs | |
State | Published - 1 Jan 1992 |
Externally published | Yes |
Keywords
- Amygdala Epilepsy Scizures Steroid Amidine R 5135
ASJC Scopus subject areas
- General Neuroscience