Epithelial photorefractive keratectomy vs mechanical epithelial removal followed by corneal crosslinking for keratoconus: the Tel-Aviv Protocol

Gilad Rabina, Michael Mimouni, Igor Kaiserman

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To compare the Tel-Aviv Protocol, epithelial photorefractive keratectomy (ePRK) combined with corneal crosslinking (CXL), to CXL with alcohol-assisted epithelial removal (Alc-CXL) for progressive keratoconus. SETTING: Care-Vision Laser Centers, Tel Aviv, Israel. DESIGN: Retrospective study. METHODS: All patients underwent Alc-CXL or ePRK, a 50 μm laser ablation of the epithelium with a myopic spherical component and an astigmatic component, followed by CXL. All patients completed at least 1 year of follow-up. RESULTS: A total of 131 eyes of 131 patients were included in the study. Fifty patients (38%) were included in the Tel-Aviv Protocol group, and 81 patients (62%) were included in the Alc-CXL group. There was a significant improvement in uncorrected distance visual acuity (UDVA) (from 1.22 ± 0.75 logarithm of the minimum angle of resolution [logMAR] to 0.49 ± 0.44 logMAR, P < .001), corrected distance visual acuity (CDVA) (from 0.29 ± 0.17 logMAR to 0.16 ± 0.12 logMAR, P < .001), Kmax (from 48.50 ± 3.00 diopters [D] to 46.50 ± 3.00 D, P < .001), and cylinder (from -3.31 ± 1.70 D to -2.32 ± 1.66 D, P < .001) in the Tel-Aviv Protocol group in comparison with nonsignificant changes in the Alc-CXL group in UDVA (from 0.89 ± 0.62 logMAR to 0.81 ± 0.65 logMAR, P = .23), CDVA (from 0.25 ± 0.21 logMAR to 0.21 ± 0.17 logMAR, P = .10), Kmax (from 46.50 ± 4.50 D to 46.00 ± 4.40 D, P = .08), and cylinder (from -2.99 ± 2.05 D to -2.80 ± 1.75 D, P = .39) at the end of the follow-up period. CONCLUSIONS: The Tel-Aviv Protocol for progressive keratoconus patients provided good improvement in visual acuity and astigmatism while halting the progression of keratoconus.

Original languageEnglish
Pages (from-to)749-755
Number of pages7
JournalJournal of Cataract and Refractive Surgery
Volume46
Issue number5
DOIs
StatePublished - 1 May 2020

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