Epoxide-diol pathway of δ1 -THC in the rat in vitro

Z. Ben-Zvi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


1. 1α2αEpoxyhexahydrocannabinol was identified as a metabolite of Δ1-tetrahydrocannabinol. 2. The two trans-1,2-dihydroxyhexahydrocannabinol isomers, 1α2dihydroxy-hexahydrocannabinol and 12αdihydroxyhexahydrocannabinol (as their acetates) were tentatively identified as metabolites from incubation of 1α2αepoxyhexahydrocannabinol with rat hepatic microsomes in vitro. 3. The 1α2αepoxyhexahydrocannabinol acetate was found to be a good substrate for epoxide hydratase as compared to styrene oxide. 4. The synthesis of metabolites of 1α2αepoxyhexahydrocannabinol is described.

Original languageEnglish
Pages (from-to)805-809
Number of pages5
Issue number11
StatePublished - 1 Jan 1980

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis


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