EPR study of anion radicals of various N-quinonyl amino acids

S. Bittner; S. Gorohovsky; E. Lozinsky; A. I. Shames

doi:10.1007/s007260070022

EPR study of anion radicals of various N-quinonyl amino acids

S. Bittner, S. Gorohovsky, E. Lozinsky, A. I. Shames

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Since peptide quinones possess great clinical potential in targeted chemotherapy, several series of novel N-quinonyl amino acids have been synthesized and their first products of reduction were studied by EPR spectroscopy. EPR spectra of the corresponding radical adducts were identified by computer simulation. The dependence between the splitting constants and the chemical structure of the N-quinonyl amino acids anion radicals was examined.

Original language	English
Pages (from-to)	439-449
Number of pages	11
Journal	Amino Acids
Volume	19
Issue number	2
DOIs	https://doi.org/10.1007/s007260070022
State	Published - 1 Jan 2000

Keywords

Amino acids
EPR
Hyperfine splittings
N-Quinonyl amino acids
Semiquinone radical

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Organic Chemistry

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10.1007/s007260070022

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abstract = "Since peptide quinones possess great clinical potential in targeted chemotherapy, several series of novel N-quinonyl amino acids have been synthesized and their first products of reduction were studied by EPR spectroscopy. EPR spectra of the corresponding radical adducts were identified by computer simulation. The dependence between the splitting constants and the chemical structure of the N-quinonyl amino acids anion radicals was examined.",

keywords = "Amino acids, EPR, Hyperfine splittings, N-Quinonyl amino acids, Semiquinone radical",

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AU - Bittner, S.

AU - Gorohovsky, S.

AU - Lozinsky, E.

AU - Shames, A. I.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Since peptide quinones possess great clinical potential in targeted chemotherapy, several series of novel N-quinonyl amino acids have been synthesized and their first products of reduction were studied by EPR spectroscopy. EPR spectra of the corresponding radical adducts were identified by computer simulation. The dependence between the splitting constants and the chemical structure of the N-quinonyl amino acids anion radicals was examined.

AB - Since peptide quinones possess great clinical potential in targeted chemotherapy, several series of novel N-quinonyl amino acids have been synthesized and their first products of reduction were studied by EPR spectroscopy. EPR spectra of the corresponding radical adducts were identified by computer simulation. The dependence between the splitting constants and the chemical structure of the N-quinonyl amino acids anion radicals was examined.

KW - Amino acids

KW - EPR

KW - Hyperfine splittings

KW - N-Quinonyl amino acids

KW - Semiquinone radical

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ER -

EPR study of anion radicals of various N-quinonyl amino acids

Abstract

Keywords

ASJC Scopus subject areas

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