Joseph Kost, Robert Langer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

80 Scopus citations


Controlled released systems represent a relatively new development that evolved out of a continuing need to prolong and better control drug administration. In conventional drug delivery modes such as a spray, an injection, or the taking of a pill, each time a person takes medicine, the drug concentration in the blood rises, peaks, and then declines. Since each drug has a therapeutic range above which it is toxic and below which it is ineffective, the plasma drug concentration in any patient at a particular time depends on compliance with the prescribed routine. This is particularly problematic if the toxic and minimum effective levels are close together. The goal of a controlled release system is to maintain the drug concentration between these two levels for a prolonged time using a single dosage form.

Original languageEnglish
Title of host publicationHydrogels in Med and Pharm
PublisherCRC Press Inc
Number of pages14
ISBN (Print)0849355486
StatePublished - 1 Dec 1986

ASJC Scopus subject areas

  • Engineering (all)


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