Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis

Malena Cohen-Cymberknoh; Noa Gilead; Silvia Gartner; Sandra Rovira; Hannah Blau; Huda Mussaffi; Joseph Rivlin; Michal Gur; Michal Shteinberg; Lea Bentur; Galit Livnat; Micha Aviram; Elie Picard; Ariel Tenenbaum; Shoshana Armoni; Oded Breuer; David Shoseyov; Eitan Kerem

doi:10.1016/j.jcf.2016.04.006

Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis

Malena Cohen-Cymberknoh, Noa Gilead, Silvia Gartner, Sandra Rovira, Hannah Blau, Huda Mussaffi, Joseph Rivlin, Michal Gur, Michal Shteinberg, Lea Bentur, Galit Livnat, Micha Aviram, Elie Picard, Ariel Tenenbaum, Shoshana Armoni, Oded Breuer, David Shoseyov, Eitan Kerem

Medical School for International Health

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Eradication of Pseudomonas aeruginosa (PA) is critical in cystic fibrosis (CF) patients. Objectives To determine eradication success rate of newly acquired PA and to identify characteristics associated with eradication failure. Methods In an observational study, data from patients with newly acquired PA infection from 2007 to 2013 were collected. Clinical variables were compared in patients with and without successful eradication for ≥ 1 year. Results Of 183 patients out of 740 (25%) from 7 CF Centers that had newly acquired PA, eradication succeeded in 72%. Patients with the highest risk of failure had multi-resistant PA, fewer sputum cultures taken, were older, and were diagnosed at a later age. The risk of eradication failure increased by 1.3% with each year of delayed CF diagnosis; successful eradication increased by 17% with each additional sputum culture taken. Conclusions Delayed detection of PA infection leading to delayed treatment and growth of multi-resistant organisms is associated with eradication failure.

Original language	English
Pages (from-to)	776-782
Number of pages	7
Journal	Journal of Cystic Fibrosis
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.jcf.2016.04.006
State	Published - 1 Nov 2016

Keywords

Cystic fibrosis
Eradication failure
Pseudomonas infection

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcf.2016.04.006

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Cohen-Cymberknoh, M., Gilead, N., Gartner, S., Rovira, S., Blau, H., Mussaffi, H., Rivlin, J., Gur, M., Shteinberg, M., Bentur, L., Livnat, G., Aviram, M., Picard, E., Tenenbaum, A., Armoni, S., Breuer, O., Shoseyov, D., & Kerem, E. (2016). Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis. Journal of Cystic Fibrosis, 15(6), 776-782. https://doi.org/10.1016/j.jcf.2016.04.006

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title = "Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis",

abstract = "Eradication of Pseudomonas aeruginosa (PA) is critical in cystic fibrosis (CF) patients. Objectives To determine eradication success rate of newly acquired PA and to identify characteristics associated with eradication failure. Methods In an observational study, data from patients with newly acquired PA infection from 2007 to 2013 were collected. Clinical variables were compared in patients with and without successful eradication for ≥ 1 year. Results Of 183 patients out of 740 (25%) from 7 CF Centers that had newly acquired PA, eradication succeeded in 72%. Patients with the highest risk of failure had multi-resistant PA, fewer sputum cultures taken, were older, and were diagnosed at a later age. The risk of eradication failure increased by 1.3% with each year of delayed CF diagnosis; successful eradication increased by 17% with each additional sputum culture taken. Conclusions Delayed detection of PA infection leading to delayed treatment and growth of multi-resistant organisms is associated with eradication failure.",

keywords = "Cystic fibrosis, Eradication failure, Pseudomonas infection",

author = "Malena Cohen-Cymberknoh and Noa Gilead and Silvia Gartner and Sandra Rovira and Hannah Blau and Huda Mussaffi and Joseph Rivlin and Michal Gur and Michal Shteinberg and Lea Bentur and Galit Livnat and Micha Aviram and Elie Picard and Ariel Tenenbaum and Shoshana Armoni and Oded Breuer and David Shoseyov and Eitan Kerem",

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doi = "10.1016/j.jcf.2016.04.006",

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Cohen-Cymberknoh, M, Gilead, N, Gartner, S, Rovira, S, Blau, H, Mussaffi, H, Rivlin, J, Gur, M, Shteinberg, M, Bentur, L, Livnat, G, Aviram, M, Picard, E, Tenenbaum, A, Armoni, S, Breuer, O, Shoseyov, D & Kerem, E 2016, 'Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis', Journal of Cystic Fibrosis, vol. 15, no. 6, pp. 776-782. https://doi.org/10.1016/j.jcf.2016.04.006

TY - JOUR

T1 - Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis

AU - Cohen-Cymberknoh, Malena

AU - Gilead, Noa

AU - Gartner, Silvia

AU - Rovira, Sandra

AU - Blau, Hannah

AU - Mussaffi, Huda

AU - Rivlin, Joseph

AU - Gur, Michal

AU - Shteinberg, Michal

AU - Bentur, Lea

AU - Livnat, Galit

AU - Aviram, Micha

AU - Picard, Elie

AU - Tenenbaum, Ariel

AU - Armoni, Shoshana

AU - Breuer, Oded

AU - Shoseyov, David

AU - Kerem, Eitan

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Eradication of Pseudomonas aeruginosa (PA) is critical in cystic fibrosis (CF) patients. Objectives To determine eradication success rate of newly acquired PA and to identify characteristics associated with eradication failure. Methods In an observational study, data from patients with newly acquired PA infection from 2007 to 2013 were collected. Clinical variables were compared in patients with and without successful eradication for ≥ 1 year. Results Of 183 patients out of 740 (25%) from 7 CF Centers that had newly acquired PA, eradication succeeded in 72%. Patients with the highest risk of failure had multi-resistant PA, fewer sputum cultures taken, were older, and were diagnosed at a later age. The risk of eradication failure increased by 1.3% with each year of delayed CF diagnosis; successful eradication increased by 17% with each additional sputum culture taken. Conclusions Delayed detection of PA infection leading to delayed treatment and growth of multi-resistant organisms is associated with eradication failure.

AB - Eradication of Pseudomonas aeruginosa (PA) is critical in cystic fibrosis (CF) patients. Objectives To determine eradication success rate of newly acquired PA and to identify characteristics associated with eradication failure. Methods In an observational study, data from patients with newly acquired PA infection from 2007 to 2013 were collected. Clinical variables were compared in patients with and without successful eradication for ≥ 1 year. Results Of 183 patients out of 740 (25%) from 7 CF Centers that had newly acquired PA, eradication succeeded in 72%. Patients with the highest risk of failure had multi-resistant PA, fewer sputum cultures taken, were older, and were diagnosed at a later age. The risk of eradication failure increased by 1.3% with each year of delayed CF diagnosis; successful eradication increased by 17% with each additional sputum culture taken. Conclusions Delayed detection of PA infection leading to delayed treatment and growth of multi-resistant organisms is associated with eradication failure.

KW - Cystic fibrosis

KW - Eradication failure

KW - Pseudomonas infection

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SP - 776

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JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 6

ER -

Eradication failure of newly acquired Pseudomonas aeruginosa isolates in cystic fibrosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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