TY - JOUR
T1 - Eradication of Ureaplasma urealyticum from the amniotic fluid with transplacental antibiotic treatment
AU - Romero, Roberto
AU - Hagay, Zion
AU - Nores, Jose
AU - Sepulveda, Waldo
AU - Mazor, Moshe
N1 - Funding Information:
From the Departments of Obstetrics and Gynecology, Yale University School of Medicine and Wayne State University. Supported by a grant from the Walter Scott Foundation for Medical Research. Dr. Romero is the recipient of a Physician Scientist Award from the National Institute of Child Health and Human Development. Received for publication December 6, 1990; revised July 1, 1991; accepted July 17,1991. Reprint requests: Roberto Romero, MD, Department of Obstetrics and Gynecology, Wayne State University, 4707 St. Antoine Blvd., Detroit, M148201.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Ureaplasma urealyticum was isolated from the amniotic fluid of a patient with preterm premature rupture of membranes at 24 weeks. A second amniocentesis performed 48 hours later indicated an increase in the number of neutrophils in the amniotic fluid. Treatment with erythromycin, ampicillin, gentamicin, and clindamycin was instituted for a period of 6 days. Amniotic fluid analysis from a third amniocentesis performed 24 hours after discontinuation of antibiotic treatment revealed only a few white blood cells and was negative for microorganisms. The pregnancy continued for 22 days after admission, at which time spontaneous labor began. The neonate survived with no sequelae and had negative blood cultures. Antibiotic treatment was associated with eradication of Ureaplasma urealyticum from the amniotic cavity, pregnancy prolongation, and neonatal survival.
AB - Ureaplasma urealyticum was isolated from the amniotic fluid of a patient with preterm premature rupture of membranes at 24 weeks. A second amniocentesis performed 48 hours later indicated an increase in the number of neutrophils in the amniotic fluid. Treatment with erythromycin, ampicillin, gentamicin, and clindamycin was instituted for a period of 6 days. Amniotic fluid analysis from a third amniocentesis performed 24 hours after discontinuation of antibiotic treatment revealed only a few white blood cells and was negative for microorganisms. The pregnancy continued for 22 days after admission, at which time spontaneous labor began. The neonate survived with no sequelae and had negative blood cultures. Antibiotic treatment was associated with eradication of Ureaplasma urealyticum from the amniotic cavity, pregnancy prolongation, and neonatal survival.
KW - Ureaplasma urealyticum
KW - antibiotic treatment
KW - chorioamnionitis
KW - premature rupture of membranes
KW - prematurity
UR - http://www.scopus.com/inward/record.url?scp=0026542930&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(92)91686-5
DO - 10.1016/0002-9378(92)91686-5
M3 - Article
C2 - 1536243
AN - SCOPUS:0026542930
VL - 166
SP - 618
EP - 620
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -