Eradication of Ureaplasma urealyticum from the amniotic fluid with transplacental antibiotic treatment

Roberto Romero, Zion Hagay, Jose Nores, Waldo Sepulveda, Moshe Mazor

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Ureaplasma urealyticum was isolated from the amniotic fluid of a patient with preterm premature rupture of membranes at 24 weeks. A second amniocentesis performed 48 hours later indicated an increase in the number of neutrophils in the amniotic fluid. Treatment with erythromycin, ampicillin, gentamicin, and clindamycin was instituted for a period of 6 days. Amniotic fluid analysis from a third amniocentesis performed 24 hours after discontinuation of antibiotic treatment revealed only a few white blood cells and was negative for microorganisms. The pregnancy continued for 22 days after admission, at which time spontaneous labor began. The neonate survived with no sequelae and had negative blood cultures. Antibiotic treatment was associated with eradication of Ureaplasma urealyticum from the amniotic cavity, pregnancy prolongation, and neonatal survival.

Original languageEnglish
Pages (from-to)618-620
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Issue number2
StatePublished - 1 Jan 1992
Externally publishedYes


  • Ureaplasma urealyticum
  • antibiotic treatment
  • chorioamnionitis
  • premature rupture of membranes
  • prematurity

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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