Erythrocyte involvement in chronic lymphocytic leukaemia

N. Meyerstein, U. Oppenheim, T. Yirmiahu, L. Hatskelson, A. Dvilansky

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disorder which sometimes also affects the erythrocytes. In this study we investigated erythrocyte involvement in 23 CLL patients. We found increased erythrocyte osmotic fragility in 15 CLL patients, but this finding was not accompanied by increased permeability to acidified glycerol (decreased AGLT50). Only those CLL patient who had positive direct antiglobulin test (DAT) had significantly decreased AGLT50. AGLT cannot serve as a predictor test for the future development of autoimmune haemolytic anaemia in CLL patients. ATP content was unaffected by the lymphoproliferative disease, but whole blood filterability was markedly decreased in CLL patients. Our study supports the hypothesis that erythrocytes are indeed affected by the lymphoproliferative disorder, even in the absence of overt autoimmune haemolytic processes.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalScandinavian Journal of Haematology
Volume36
Issue number2
DOIs
StatePublished - 1 Jan 1986
Externally publishedYes

Keywords

  • CLL ‐
  • antiglobulin test ‐
  • autoimmune haemolytic anaemia ‐
  • erythrocyte ‐
  • glycerol lysis test

ASJC Scopus subject areas

  • Hematology

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