Estimation of delay in detecting hepatitis C virus antibodies in pools compared to individual testing on seroconversion panels

B. Sarov; L. Novack; N. Galai; A. Yaari; M. Orgel; J. Safi; V. Yahalom; E. Shinar

doi:10.1111/j.1469-0691.2007.01740.x

Estimation of delay in detecting hepatitis C virus antibodies in pools compared to individual testing on seroconversion panels

B. Sarov, L. Novack, N. Galai, A. Yaari, M. Orgel, J. Safi, V. Yahalom, E. Shinar

Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Testing for anti-hepatitis C virus (HCV) antibodies in pools may reduce blood screening costs, making this approach affordable for developing countries, provided that the dilution of infected blood does not significantly increase the number of undetectable viral particles, especially in seroconverters. This study assessed the delay in detection of HCV antibodies in five HCV seroconversion panels, tested in pools of 6-48 samples, and estimated the risk of transfusion-transmitted HCV caused by pooling. The delay in detection of positive samples was 5-12 days for pools of all sizes, adding 7% to the risk of HCV transmission that occurs when blood donors' samples are tested individually.

Original language	English
Pages (from-to)	737-739
Number of pages	3
Journal	Clinical Microbiology and Infection
Volume	13
Issue number	7
DOIs	https://doi.org/10.1111/j.1469-0691.2007.01740.x
State	Published - 1 Jan 2007

Keywords

Antibodies
Blood donors
Detection
Hepatitis C virus
Pooled screening
Seroconversion

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1469-0691.2007.01740.x

Cite this

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title = "Estimation of delay in detecting hepatitis C virus antibodies in pools compared to individual testing on seroconversion panels",

abstract = "Testing for anti-hepatitis C virus (HCV) antibodies in pools may reduce blood screening costs, making this approach affordable for developing countries, provided that the dilution of infected blood does not significantly increase the number of undetectable viral particles, especially in seroconverters. This study assessed the delay in detection of HCV antibodies in five HCV seroconversion panels, tested in pools of 6-48 samples, and estimated the risk of transfusion-transmitted HCV caused by pooling. The delay in detection of positive samples was 5-12 days for pools of all sizes, adding 7% to the risk of HCV transmission that occurs when blood donors' samples are tested individually.",

keywords = "Antibodies, Blood donors, Detection, Hepatitis C virus, Pooled screening, Seroconversion",

author = "B. Sarov and L. Novack and N. Galai and A. Yaari and M. Orgel and J. Safi and V. Yahalom and E. Shinar",

note = "Funding Information: This study was funded by the US Agency for International Development, Middle East Regional Cooperation Program (US-AID MERC), and forms part of the PhD dissertation of L. Novack. The first and second authors contributed equally to the manuscript.",

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doi = "10.1111/j.1469-0691.2007.01740.x",

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AU - Sarov, B.

AU - Novack, L.

AU - Galai, N.

AU - Yaari, A.

AU - Orgel, M.

AU - Safi, J.

AU - Yahalom, V.

AU - Shinar, E.

N1 - Funding Information: This study was funded by the US Agency for International Development, Middle East Regional Cooperation Program (US-AID MERC), and forms part of the PhD dissertation of L. Novack. The first and second authors contributed equally to the manuscript.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Testing for anti-hepatitis C virus (HCV) antibodies in pools may reduce blood screening costs, making this approach affordable for developing countries, provided that the dilution of infected blood does not significantly increase the number of undetectable viral particles, especially in seroconverters. This study assessed the delay in detection of HCV antibodies in five HCV seroconversion panels, tested in pools of 6-48 samples, and estimated the risk of transfusion-transmitted HCV caused by pooling. The delay in detection of positive samples was 5-12 days for pools of all sizes, adding 7% to the risk of HCV transmission that occurs when blood donors' samples are tested individually.

AB - Testing for anti-hepatitis C virus (HCV) antibodies in pools may reduce blood screening costs, making this approach affordable for developing countries, provided that the dilution of infected blood does not significantly increase the number of undetectable viral particles, especially in seroconverters. This study assessed the delay in detection of HCV antibodies in five HCV seroconversion panels, tested in pools of 6-48 samples, and estimated the risk of transfusion-transmitted HCV caused by pooling. The delay in detection of positive samples was 5-12 days for pools of all sizes, adding 7% to the risk of HCV transmission that occurs when blood donors' samples are tested individually.

KW - Antibodies

KW - Blood donors

KW - Detection

KW - Hepatitis C virus

KW - Pooled screening

KW - Seroconversion

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U2 - 10.1111/j.1469-0691.2007.01740.x

DO - 10.1111/j.1469-0691.2007.01740.x

M3 - Article

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SN - 1198-743X

VL - 13

SP - 737

EP - 739

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 7

ER -

Estimation of delay in detecting hepatitis C virus antibodies in pools compared to individual testing on seroconversion panels

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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