Estimation of the scattering coefficients of turbid media using angle-resolved optical frequency-domain imaging

A. E. Desjardins; B. J. Vakoc; A. Bilenca; G. J. Tearney; B. E. Bouma

doi:10.1364/OL.32.001560

Estimation of the scattering coefficients of turbid media using angle-resolved optical frequency-domain imaging

A. E. Desjardins, B. J. Vakoc, A. Bilenca, G. J. Tearney, B. E. Bouma

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Noninvasive measurements of the scattering coefficients of optically turbid media using angle-resolved optical frequency-domain imaging (OFDI) are demonstrated. It is shown that, by incoherently averaging OFDI reflectance signals acquired at different backscattering angles, speckle noise is reduced, allowing scattering coefficients to be extracted from a single A-line with much higher accuracy than with measurements from conventional OFDI and optical coherence tomography systems. Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom.

Original language	English
Pages (from-to)	1560-1562
Number of pages	3
Journal	Optics Letters
Volume	32
Issue number	11
DOIs	https://doi.org/10.1364/OL.32.001560
State	Published - 1 Jun 2007
Externally published	Yes

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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abstract = "Noninvasive measurements of the scattering coefficients of optically turbid media using angle-resolved optical frequency-domain imaging (OFDI) are demonstrated. It is shown that, by incoherently averaging OFDI reflectance signals acquired at different backscattering angles, speckle noise is reduced, allowing scattering coefficients to be extracted from a single A-line with much higher accuracy than with measurements from conventional OFDI and optical coherence tomography systems. Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom.",

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AU - Desjardins, A. E.

AU - Vakoc, B. J.

AU - Bilenca, A.

AU - Tearney, G. J.

AU - Bouma, B. E.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Noninvasive measurements of the scattering coefficients of optically turbid media using angle-resolved optical frequency-domain imaging (OFDI) are demonstrated. It is shown that, by incoherently averaging OFDI reflectance signals acquired at different backscattering angles, speckle noise is reduced, allowing scattering coefficients to be extracted from a single A-line with much higher accuracy than with measurements from conventional OFDI and optical coherence tomography systems. Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom.

AB - Noninvasive measurements of the scattering coefficients of optically turbid media using angle-resolved optical frequency-domain imaging (OFDI) are demonstrated. It is shown that, by incoherently averaging OFDI reflectance signals acquired at different backscattering angles, speckle noise is reduced, allowing scattering coefficients to be extracted from a single A-line with much higher accuracy than with measurements from conventional OFDI and optical coherence tomography systems. Modeling speckle as a random phasor sum, the relationship between the measurement accuracy and the number of compounded angles is derived. The sensitivity analysis is validated with measurements from a tissue phantom.

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JO - Optics Letters

JF - Optics Letters

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ER -

Estimation of the scattering coefficients of turbid media using angle-resolved optical frequency-domain imaging

Abstract

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