Estimation of vaccine efficacy against acquisition of pneumococcal carriage

Hanna Rinta-Kokko, Ron Dagan, Noga Givon-Lavi, Kari Auranen

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Evaluation of the effect of new conjugate vaccines on nasopharyngeal carriage of Streptococcus pneumoniae (pneumococcus) has been based on simple comparisons of the prevalence of carriage in vaccinees and controls. However, the definition and measurement of vaccine efficacy should be based on knowledge of the actual mechanism of the vaccine's effect. According to current knowledge, conjugate vaccines affect acquisition. We propose a simple-to-use method to measure vaccine efficacy against serotype-specific acquisition that needs only cross-sectional measurements of carriage. We demonstrate the use of the method by application to a data set where it is also possible to estimate efficacy against acquisition from longitudinal measurements.

Original languageEnglish
Pages (from-to)3831-3837
Number of pages7
JournalVaccine
Volume27
Issue number29
DOIs
StatePublished - 12 Jun 2009
Externally publishedYes

Keywords

  • Nasopharyngeal colonization
  • Streptococcus pneumoniae
  • Vaccine efficacy

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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