ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

Swati Srivastava; Nishanth Belugali Nataraj; Arunachalam Sekar; Soma Ghosh; Chamutal Bornstein; Diana Drago-Garcia; Lee Roth; Donatella Romaniello; Ilaria Marrocco; Eyal David; Yuval Gilad; Mattia Lauriola; Ron Rotkopf; Adi Kimchi; Yuya Haga; Yasuo Tsutsumi; Olivier Mirabeau; Didier Surdez; Andrei Zinovyev; Olivier Delattre; Heinrich Kovar; Ido Amit; Yosef Yarden

doi:10.1016/j.celrep.2019.08.088

ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

Swati Srivastava, Nishanth Belugali Nataraj, Arunachalam Sekar, Soma Ghosh, Chamutal Bornstein, Diana Drago-Garcia, Lee Roth, Donatella Romaniello, Ilaria Marrocco, Eyal David, Yuval Gilad, Mattia Lauriola, Ron Rotkopf, Adi Kimchi, Yuya Haga, Yasuo Tsutsumi, Olivier Mirabeau, Didier Surdez, Andrei Zinovyev, Olivier DelattreHeinrich Kovar, Ido Amit, Yosef Yarden

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The single oncogene of Ewing sarcoma (ES), a childhood cancer, encodes a FLI1 fusion protein. Srivastava et al. report physical interactions between the fusion protein and the glucocorticoid receptor. Drug-induced inhibition of these interactions retards the progression of ES in mouse models.

Original language	English
Pages (from-to)	104-117.e4
Journal	Cell Reports
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2019.08.088
State	Published - 1 Oct 2019
Externally published	Yes

Keywords

cancer therapy
Ewing sarcoma
glucocorticoid receptor
metastasis
protein-fragment complementation assay

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2019.08.088

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Srivastava, S., Nataraj, N. B., Sekar, A., Ghosh, S., Bornstein, C., Drago-Garcia, D., Roth, L., Romaniello, D., Marrocco, I., David, E., Gilad, Y., Lauriola, M., Rotkopf, R., Kimchi, A., Haga, Y., Tsutsumi, Y., Mirabeau, O., Surdez, D., Zinovyev, A., ... Yarden, Y. (2019). ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma. Cell Reports, 29(1), 104-117.e4. https://doi.org/10.1016/j.celrep.2019.08.088

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title = "ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma",

abstract = "The single oncogene of Ewing sarcoma (ES), a childhood cancer, encodes a FLI1 fusion protein. Srivastava et al. report physical interactions between the fusion protein and the glucocorticoid receptor. Drug-induced inhibition of these interactions retards the progression of ES in mouse models.",

keywords = "cancer therapy, Ewing sarcoma, glucocorticoid receptor, metastasis, protein-fragment complementation assay",

author = "Swati Srivastava and Nataraj, {Nishanth Belugali} and Arunachalam Sekar and Soma Ghosh and Chamutal Bornstein and Diana Drago-Garcia and Lee Roth and Donatella Romaniello and Ilaria Marrocco and Eyal David and Yuval Gilad and Mattia Lauriola and Ron Rotkopf and Adi Kimchi and Yuya Haga and Yasuo Tsutsumi and Olivier Mirabeau and Didier Surdez and Andrei Zinovyev and Olivier Delattre and Heinrich Kovar and Ido Amit and Yosef Yarden",

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year = "2019",

month = oct,

day = "1",

doi = "10.1016/j.celrep.2019.08.088",

language = "English",

volume = "29",

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Srivastava, S, Nataraj, NB, Sekar, A, Ghosh, S, Bornstein, C, Drago-Garcia, D, Roth, L, Romaniello, D, Marrocco, I, David, E, Gilad, Y, Lauriola, M, Rotkopf, R, Kimchi, A, Haga, Y, Tsutsumi, Y, Mirabeau, O, Surdez, D, Zinovyev, A, Delattre, O, Kovar, H, Amit, I & Yarden, Y 2019, 'ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma', Cell Reports, vol. 29, no. 1, pp. 104-117.e4. https://doi.org/10.1016/j.celrep.2019.08.088

TY - JOUR

T1 - ETS Proteins Bind with Glucocorticoid Receptors

T2 - Relevance for Treatment of Ewing Sarcoma

AU - Srivastava, Swati

AU - Nataraj, Nishanth Belugali

AU - Sekar, Arunachalam

AU - Ghosh, Soma

AU - Bornstein, Chamutal

AU - Drago-Garcia, Diana

AU - Roth, Lee

AU - Romaniello, Donatella

AU - Marrocco, Ilaria

AU - David, Eyal

AU - Gilad, Yuval

AU - Lauriola, Mattia

AU - Rotkopf, Ron

AU - Kimchi, Adi

AU - Haga, Yuya

AU - Tsutsumi, Yasuo

AU - Mirabeau, Olivier

AU - Surdez, Didier

AU - Zinovyev, Andrei

AU - Delattre, Olivier

AU - Kovar, Heinrich

AU - Amit, Ido

AU - Yarden, Yosef

PY - 2019/10/1

Y1 - 2019/10/1

N2 - The single oncogene of Ewing sarcoma (ES), a childhood cancer, encodes a FLI1 fusion protein. Srivastava et al. report physical interactions between the fusion protein and the glucocorticoid receptor. Drug-induced inhibition of these interactions retards the progression of ES in mouse models.

AB - The single oncogene of Ewing sarcoma (ES), a childhood cancer, encodes a FLI1 fusion protein. Srivastava et al. report physical interactions between the fusion protein and the glucocorticoid receptor. Drug-induced inhibition of these interactions retards the progression of ES in mouse models.

KW - cancer therapy

KW - Ewing sarcoma

KW - glucocorticoid receptor

KW - metastasis

KW - protein-fragment complementation assay

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U2 - 10.1016/j.celrep.2019.08.088

DO - 10.1016/j.celrep.2019.08.088

M3 - Article

C2 - 31577941

AN - SCOPUS:85072272041

SN - 2211-1247

VL - 29

SP - 104-117.e4

JO - Cell Reports

JF - Cell Reports

IS - 1

ER -

ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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