Abstract
Sparteine is an alkaloid with bacteriostatic activity on the genus Mycobacterium. The objective of this research was to evaluate the antimicrobial activity of sparteine on the growth of 4 ATCC strains of My-cobacterium tuberculosis (susceptible, resistant to isoniazid, resistant to rifampicin and multidrug-resis-tant) in vitro. Validation of bactericidal activity of sparteine sulfate was carried out through an adaptation of the Microscopic-Observation Drug-Susceptibility (MODS) method according to the guidelines of the Peruvian National Health Institute. The results demonstrate that at concentrations of 25; 50 and 100 mM of sparteine sulfate, there is no development of colony-forming units in any of the 4 strains evaluated. The results demonstrate the potential in vitro antimicrobial effect of sparteine on multidrug-resistant tuberculosis.
| Translated title of the contribution | EVALUATION OF IN VITRO SUSCEPTIBILITY TO SPARTEIN IN FOUR STRAINS OF Mycobacterium tuberculosis |
|---|---|
| Original language | Spanish |
| Pages (from-to) | 77-82 |
| Number of pages | 6 |
| Journal | Revista Peruana de Medicina Experimental y Salud Publica |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 2022 |
| Externally published | Yes |
Keywords
- Alkaloid (source: MeSH NLM)
- Mycobacterium tuberculosis
- Resistant Tuberculosis
- Sparteine
- Sparteine Sul-fate
- Tuberculosis
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
