Evaluating the efficacy of EMLA in alleviating pain associated with lumbar puncture; comparison of open and double-blinded protocols in children

Joseph Kapelushnik, Gideon Koren, Hassan Solh, Mark Greenberg, Levert DeVeber

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Potential benefit of the topical anesthetic EMLA prior to lumbar puncture was studied in children with cancer. Comparison was made between 2 types of study: the first one involved 10 children who were enrolled in a double-blind placebo-controlled study and in the second, 18 children in an open crossover study. Although both studies suggested the favourable effects of EMLA in alleviating pain associated with LP, they illustrated the need to perform such studies in a controlled blinded fashion; the effect in the double-blind study was not apparent in some cases, whereas it was clear cut in all open cases.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalPain
Volume42
Issue number1
DOIs
StatePublished - 1 Jan 1990
Externally publishedYes

Keywords

  • Double-blind study
  • EMLA
  • Lumbar puncture
  • Open crossover study
  • Placebo effect

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