Evaluation of anti-tussive activity of shirishavaleha - An ayurvedic herbal compound formulation in sulphur dioxide induced cough in mice

Y. S. Singh, Galib, P. K. Prajapati, B. Ravishankar, B. K. Ashok

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The present study was carried out to evaluate anti-tussive activity of Shirishavaleha prepared by two different parts of Shirisha (Albizzia lebbeck Benth.) i.e. bark (Twak) and heartwood (Sara) in sulphur dioxide (SO 2) induced cough model in mice. Randomly selected animals were divided in to four groups of 6 animals each. The test drug was administered orally at a dose of 2.6 g/kg. Recodex, which contains codeine phosphate (2 mg/mL) and chlorpheniramine maleate (0.8 mg/mL), was used as standard antitussive drug for comparison. Both the test drugs have shown significant anti-tussive activity against the sulphur dioxide induced cough reflexus. Thus, Shirishavaleha prepared from either bark or heart wood of Shirisha can be potentially used for alleviating cough in the treatment of asthmatic.

Original languageEnglish
Pages (from-to)38-41
Number of pages4
JournalIndian Drugs
Volume47
Issue number9
StatePublished - 1 Jan 2010

Keywords

  • Albizzia lebbeck Benth
  • Anti-tussive activity
  • Avaleha
  • Cough
  • Shirisha

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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