We present an evaluation of the cost-effectiveness of an automated multiphasic health testing system (AMHTS) compared with a manual system for providing comprehensive health examinations of large populations. The automated technology was found to be more economical (50–75% less/examinee) than the traditional system in performing each phase of the comprehensive screening and overall battery at a certain examinee load per month. Direct costs had a larger effect on cost per examinee than indirect costs and equipment depreciation. Highly automated phases (tests) were relatively more cost-effective than phases requiring more time and participation of physicians or trained personnel. This study demonstrates that an AMHTS can be utilized (within its parent medical care delivery organization) as an efficient, economical, and convenient method for conducting large-scale multiphasic screening.