TY - JOUR
T1 - Evidence for an association between the dopamine d3 receptor gene DRD3 and schizophrenia
AU - Ebstein, Richard P.
AU - Macciardi, Fabio
AU - Heresco-Levi, Uriel
AU - Serretti, Alessandro
AU - Blaine, Darren
AU - Verga, Massimiliano
AU - Nebamov, Lubov
AU - Gur, Eitan
AU - Belmaker, Robert H.
AU - Avnon, Moshe
AU - Lerer, Bernard
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Association of the dopamine D3 receptor gene (DRD3) and schizophrenia was examined in unrelated Israeli and Italian schizophrenic patients and ethnically matched normal control subjects. In the combined sample, there was a siginificant excess of DRD3 allele 2 among the schizophrenic patients (χ2 = 4.70, d.f. 1, p = 0.03). Comparison of genotype frequencies revealed an excess of the 2-2 genotype in the combined schizophrenic sample (χ2 = 8.30, d.f. 1, p = 0.01) and in the non-Ashkenazi Israeli schizophrenics alone (χ2 = 5.70, d.f. 2, p = 0.05). DRD3 2-2 genotype conferred a significantly increased risk of schizophrenia (χ2 = 8.21, d.f. 1, p = 0.004; OR = 2.87, CI 95% = 1.36-5.76) in the combined sample and in the non-Ashkenazi Israeli schizophrenics (χ2 = 7.22, d.f. 1, p = 0.04; OR = 7.22, CI 95% = 1.04-24.83). In the combined and Italian samples, allele 2 was associated with early age of onset as was the 2-2 genotype in the combined sample and non-Ash-kenazi group. The 2-2 genotype was associated with poor response to neuroleptics, particularly in the non-Ashkenazi, Israeli schizophrenics. The possibility that DRD3 or a locus in linkage disequilibrium with it may play a role in the transmission of schizophrenia, is considered in relation to previous positive and negative reports.
AB - Association of the dopamine D3 receptor gene (DRD3) and schizophrenia was examined in unrelated Israeli and Italian schizophrenic patients and ethnically matched normal control subjects. In the combined sample, there was a siginificant excess of DRD3 allele 2 among the schizophrenic patients (χ2 = 4.70, d.f. 1, p = 0.03). Comparison of genotype frequencies revealed an excess of the 2-2 genotype in the combined schizophrenic sample (χ2 = 8.30, d.f. 1, p = 0.01) and in the non-Ashkenazi Israeli schizophrenics alone (χ2 = 5.70, d.f. 2, p = 0.05). DRD3 2-2 genotype conferred a significantly increased risk of schizophrenia (χ2 = 8.21, d.f. 1, p = 0.004; OR = 2.87, CI 95% = 1.36-5.76) in the combined sample and in the non-Ashkenazi Israeli schizophrenics (χ2 = 7.22, d.f. 1, p = 0.04; OR = 7.22, CI 95% = 1.04-24.83). In the combined and Italian samples, allele 2 was associated with early age of onset as was the 2-2 genotype in the combined sample and non-Ash-kenazi group. The 2-2 genotype was associated with poor response to neuroleptics, particularly in the non-Ashkenazi, Israeli schizophrenics. The possibility that DRD3 or a locus in linkage disequilibrium with it may play a role in the transmission of schizophrenia, is considered in relation to previous positive and negative reports.
KW - DRD3
KW - Psychiatric genetics
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=17644435549&partnerID=8YFLogxK
U2 - 10.1159/000154382
DO - 10.1159/000154382
M3 - Article
AN - SCOPUS:17644435549
SN - 0001-5652
VL - 47
SP - 6
EP - 16
JO - Human Heredity
JF - Human Heredity
IS - 1
ER -