(1) In CD-1 mice and Sprague - Dawley rats, dark-induced elevation of body temperature (Tb) was accompanied by an increase in hypothalamic prostaglandin E2 (PGE2) production. (2) Indomethacin, a cyclooxygenase inhibitor, at a dose (5 mg/kg) that did not affect the daytime values of Tb, prevented the increase of Th after the onset of darkness. (3) Pretreatment of mice with the inhibitor of leukotriene synthesis, MK-886 (1 mg/kg), prevented the decrease of daytime Tb. (4) The results suggest the involvement of PGE2 and leukotrienes in the regulation of normal daily variations of Tb.
- Circadian rhythm
- Inhibitors of eicosanoid synthesis
- Normal body temperature
- Prostaglandin E
ASJC Scopus subject areas
- Agricultural and Biological Sciences (all)
- Developmental Biology