Evidence for the involvement of eicosanoids in the regulation of normal body temperature

V. Fraifeld; L. Paul; J. Kaplanski; W. Kozak; M. J. Kluger

doi:10.1016/S0306-4565(01)00033-X

Evidence for the involvement of eicosanoids in the regulation of normal body temperature

V. Fraifeld, L. Paul, J. Kaplanski, W. Kozak, M. J. Kluger

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

(1) In CD-1 mice and Sprague - Dawley rats, dark-induced elevation of body temperature (T_b) was accompanied by an increase in hypothalamic prostaglandin E₂ (PGE₂) production. (2) Indomethacin, a cyclooxygenase inhibitor, at a dose (5 mg/kg) that did not affect the daytime values of T_b, prevented the increase of Th after the onset of darkness. (3) Pretreatment of mice with the inhibitor of leukotriene synthesis, MK-886 (1 mg/kg), prevented the decrease of daytime T_b. (4) The results suggest the involvement of PGE₂ and leukotrienes in the regulation of normal daily variations of T_b.

Original language	English
Pages (from-to)	295-297
Number of pages	3
Journal	Journal of Thermal Biology
Volume	26
Issue number	4-5
DOIs	https://doi.org/10.1016/S0306-4565(01)00033-X
State	Published - 12 Sep 2001

Keywords

Circadian rhythm
Hypothalamus
Indomethacin
Inhibitors of eicosanoid synthesis
Leukotrienes
Mice
MK-886
Normal body temperature
Prostaglandin E
Rats

ASJC Scopus subject areas

Biochemistry
Physiology
General Agricultural and Biological Sciences
Developmental Biology

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10.1016/S0306-4565(01)00033-X

Cite this

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title = "Evidence for the involvement of eicosanoids in the regulation of normal body temperature",

abstract = "(1) In CD-1 mice and Sprague - Dawley rats, dark-induced elevation of body temperature (Tb) was accompanied by an increase in hypothalamic prostaglandin E2 (PGE2) production. (2) Indomethacin, a cyclooxygenase inhibitor, at a dose (5 mg/kg) that did not affect the daytime values of Tb, prevented the increase of Th after the onset of darkness. (3) Pretreatment of mice with the inhibitor of leukotriene synthesis, MK-886 (1 mg/kg), prevented the decrease of daytime Tb. (4) The results suggest the involvement of PGE2 and leukotrienes in the regulation of normal daily variations of Tb.",

keywords = "Circadian rhythm, Hypothalamus, Indomethacin, Inhibitors of eicosanoid synthesis, Leukotrienes, Mice, MK-886, Normal body temperature, Prostaglandin E, Rats",

author = "V. Fraifeld and L. Paul and J. Kaplanski and W. Kozak and Kluger, {M. J.}",

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doi = "10.1016/S0306-4565(01)00033-X",

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T1 - Evidence for the involvement of eicosanoids in the regulation of normal body temperature

AU - Fraifeld, V.

AU - Paul, L.

AU - Kaplanski, J.

AU - Kozak, W.

AU - Kluger, M. J.

PY - 2001/9/12

Y1 - 2001/9/12

N2 - (1) In CD-1 mice and Sprague - Dawley rats, dark-induced elevation of body temperature (Tb) was accompanied by an increase in hypothalamic prostaglandin E2 (PGE2) production. (2) Indomethacin, a cyclooxygenase inhibitor, at a dose (5 mg/kg) that did not affect the daytime values of Tb, prevented the increase of Th after the onset of darkness. (3) Pretreatment of mice with the inhibitor of leukotriene synthesis, MK-886 (1 mg/kg), prevented the decrease of daytime Tb. (4) The results suggest the involvement of PGE2 and leukotrienes in the regulation of normal daily variations of Tb.

AB - (1) In CD-1 mice and Sprague - Dawley rats, dark-induced elevation of body temperature (Tb) was accompanied by an increase in hypothalamic prostaglandin E2 (PGE2) production. (2) Indomethacin, a cyclooxygenase inhibitor, at a dose (5 mg/kg) that did not affect the daytime values of Tb, prevented the increase of Th after the onset of darkness. (3) Pretreatment of mice with the inhibitor of leukotriene synthesis, MK-886 (1 mg/kg), prevented the decrease of daytime Tb. (4) The results suggest the involvement of PGE2 and leukotrienes in the regulation of normal daily variations of Tb.

KW - Circadian rhythm

KW - Hypothalamus

KW - Indomethacin

KW - Inhibitors of eicosanoid synthesis

KW - Leukotrienes

KW - Mice

KW - MK-886

KW - Normal body temperature

KW - Prostaglandin E

KW - Rats

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DO - 10.1016/S0306-4565(01)00033-X

M3 - Article

AN - SCOPUS:0034862432

SN - 0306-4565

VL - 26

SP - 295

EP - 297

JO - Journal of Thermal Biology

JF - Journal of Thermal Biology

IS - 4-5

ER -

Evidence for the involvement of eicosanoids in the regulation of normal body temperature

Abstract

Keywords

ASJC Scopus subject areas

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