Evidence for the involvement of eicosanoids in the regulation of normal body temperature

V. Fraifeld, L. Paul, J. Kaplanski, W. Kozak, M. J. Kluger

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

(1) In CD-1 mice and Sprague - Dawley rats, dark-induced elevation of body temperature (Tb) was accompanied by an increase in hypothalamic prostaglandin E2 (PGE2) production. (2) Indomethacin, a cyclooxygenase inhibitor, at a dose (5 mg/kg) that did not affect the daytime values of Tb, prevented the increase of Th after the onset of darkness. (3) Pretreatment of mice with the inhibitor of leukotriene synthesis, MK-886 (1 mg/kg), prevented the decrease of daytime Tb. (4) The results suggest the involvement of PGE2 and leukotrienes in the regulation of normal daily variations of Tb.

Original languageEnglish
Pages (from-to)295-297
Number of pages3
JournalJournal of Thermal Biology
Volume26
Issue number4-5
DOIs
StatePublished - 12 Sep 2001

Keywords

  • Circadian rhythm
  • Hypothalamus
  • Indomethacin
  • Inhibitors of eicosanoid synthesis
  • Leukotrienes
  • MK-886
  • Mice
  • Normal body temperature
  • Prostaglandin E
  • Rats

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