TY - JOUR
T1 - Evidence of measles virus antigens and RNA in endometrial cancer
AU - Benharroch, Daniel
AU - Klinkovich, Irina
AU - Piura, Benjamin
AU - Shaco-Levy, Ruthy
AU - Gopas, Jacob
N1 - Funding Information:
This study was supported in part by The Mauricette Bismuth Foundation , Marseille; Kibbutz Sde-Boker , Israel; The Weinksenbaum Family Medical Research Fund (through the Israel Ministry of Health); The Richard H. Holtzer Memorial Foundation ; The Samuel Goldstein Foundation ; The Brenner Family Foundation .
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Objectives: To look for an association between the measles virus and endometrial carcinoma, the most frequent cancer of the female genital tract in our area. Study design: Thirty-six of 49 patients with endometrial carcinoma were studied to detect fingerprints of the measles virus. Immunohistochemistry with the avidin-biotin complex method and in situ hybridization were used to demonstrate the association. The clinicopathological correlations were carried out to support a relationship between the virus and the cancer if any was found. Results: Twenty-six of the 36 cases (72%) of endometrial cancer showed the presence of measles virus antigens in the tumor cells. Sixteen of 21 cases were positive for measles virus RNA by in situ hybridization. Although type I endometrial carcinoma was more positive for viral particles than type II, type II cancer, when allied with the measles virus, was more often associated with the depth of myometrial invasion and with death from tumor. Conclusions: We demonstrate for the first time a link between endometrial cancer and the presence of viral antigens and RNA of the measles virus, although these findings do not necessarily signify a causal relationship between the cancer and the virus.
AB - Objectives: To look for an association between the measles virus and endometrial carcinoma, the most frequent cancer of the female genital tract in our area. Study design: Thirty-six of 49 patients with endometrial carcinoma were studied to detect fingerprints of the measles virus. Immunohistochemistry with the avidin-biotin complex method and in situ hybridization were used to demonstrate the association. The clinicopathological correlations were carried out to support a relationship between the virus and the cancer if any was found. Results: Twenty-six of the 36 cases (72%) of endometrial cancer showed the presence of measles virus antigens in the tumor cells. Sixteen of 21 cases were positive for measles virus RNA by in situ hybridization. Although type I endometrial carcinoma was more positive for viral particles than type II, type II cancer, when allied with the measles virus, was more often associated with the depth of myometrial invasion and with death from tumor. Conclusions: We demonstrate for the first time a link between endometrial cancer and the presence of viral antigens and RNA of the measles virus, although these findings do not necessarily signify a causal relationship between the cancer and the virus.
KW - Endometrial carcinoma
KW - In situ hybridization
KW - Measles virus
UR - http://www.scopus.com/inward/record.url?scp=71849103621&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2009.08.008
DO - 10.1016/j.ejogrb.2009.08.008
M3 - Article
AN - SCOPUS:71849103621
SN - 0028-2243
VL - 147
SP - 206
EP - 209
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
IS - 2
ER -
