Evidence to support the rationale that bacterial eradication in respiratory tract infection is an important aim of antimicrobial therapy

Ron Dagan, Keith P. Klugman, William A. Craig, Fernando Baquero

Research output: Contribution to journalReview articlepeer-review

212 Scopus citations

Abstract

Clinical outcome is dependent upon antibiotic-mediated bacterial eradication in a number of infections. However, in respiratory tract infections, the need for bacterial eradication has been controversial. Clinical data are now available that support the need for active bacterial eradication in otitis media. This may also be the case for other respiratory tract infections. An increase in antimicrobial resistance reduces the probability of achieving eradication. Conversely, failure to eradicate bacteria may promote the emergence and dissemination of antimicrobial-resistant clones. Pharmacokinetic/pharmacodynamic parameters can be used to predict the bacteriological efficacy of antimicrobial therapy. In conclusion, the aim of antimicrobial therapy in respiratory tract infections should be the eradication of the infecting organism.

Original languageEnglish
Pages (from-to)129-140
Number of pages12
JournalJournal of Antimicrobial Chemotherapy
Volume47
Issue number2
DOIs
StatePublished - 1 Jan 2001
Externally publishedYes

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