Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Sumit Mukherjee; Milana Frenkel-Morgenstern

doi:10.1016/j.tig.2021.08.015

Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Sumit Mukherjee, Milana Frenkel-Morgenstern

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.

Original language	English
Pages (from-to)	4-7
Number of pages	4
Journal	Trends in Genetics
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.tig.2021.08.015
State	Published - 1 Jan 2022
Externally published	Yes

Keywords

cancer evolution
chimeric RNA
gene fusion
phenotypic plasticity

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tig.2021.08.015

Cite this

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title = "Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells",

abstract = "Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.",

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author = "Sumit Mukherjee and Milana Frenkel-Morgenstern",

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AU - Mukherjee, Sumit

AU - Frenkel-Morgenstern, Milana

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N2 - Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.

AB - Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.

KW - cancer evolution

KW - chimeric RNA

KW - gene fusion

KW - phenotypic plasticity

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DO - 10.1016/j.tig.2021.08.015

M3 - Short survey

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AN - SCOPUS:85115978426

SN - 0168-9525

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JO - Trends in Genetics

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Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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